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Those with MTHFR gene mutations lack the enzyme required to activate folic acid, which can result in a buildup of unmetabolized folic acid (UMFA)

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[2] The study was not controlled for cream vehicle application alone without active ingredients

Large-scale postmortem analyses indicate that cerebrovascular pathology occurs in approximately 80% of AD casesa prevalence markedly higher than in other neurodegenerative disorders such as Parkinsons disease, frontotemporal dementia, and Lewy body diseasehighlighting a potentially distinctive role of vascular dysfunction in AD pathogenesis (161)